Gintant, Gary A.: search on Z-Library

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1

Evolution of strategies to improve preclinical cardiac safety testing

Gintant, Gary, Sager, Philip T., Stockbridge, Norman

Journal:

Nature Reviews Drug Discovery

Year:

2016

Language:

english

File:

PDF, 510 KB

english, 2016

2

Drug-induced QT prolongation: Concordance of preclinical canine model in relation to clinical outcome

Koshman, Yevgeniya E., Wilsey, Amanda S., Bird, Brandan M., Gintant, Gary A., Polakowski, James S., Mittelstadt, Scott W.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2020

File:

PDF, 1.09 MB

2020

3

ILSI-HESI cardiovascular safety subcommittee initiative: Evaluation of three non-clinical models of QT prolongation

Laurie A. Hanson, Alan S. Bass, Gary Gintant, Scott Mittelstadt, David Rampe, Karluss Thomas

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2006

Language:

english

File:

PDF, 273 KB

english, 2006

4

Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs

Koshman, Yevgeniya E., Wilsey, Amanda S., Bird, Brandan M., Endemann, Aimee L., Sadilek, Sabine, Treadway, Jessica, Martin, Ruth L., Polakowski, James S., Gintant, Gary A., Mittelstadt, Scott W.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2020

File:

PDF, 900 KB

2020

5

The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o

Gilbert J. Diaz, Katina Daniell, Sandra T. Leitza, Ruth L. Martin, Zhi Su, Jeffrey S. McDermott, Bryan F. Cox, Gary A. Gintant

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2004

Language:

english

File:

PDF, 421 KB

english, 2004

6

Assessing concordance of nonclinical and clinical QT data: The ILSI-HESI cardiovascular safety subcommittee initiative re-visited

Matt Skinner, Jean-Pierre Valentin, Gary Gintant, John Koerner, Syril Pettit, Todd Wisialowski

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 73 KB

english, 2012

7

The Evolving Roles of Human iPSC-Derived Cardiomyocytes in Drug Safety and Discovery

Gintant, Gary, Fermini, Bernard, Stockbridge, Norman, Strauss, David

Journal:

Year:

2017

Language:

english

File:

PDF, 694 KB

english, 2017

8

Ions, equations and electrons: the evolving role of computer simulations in cardiac electrophysiology safety evaluations

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 159 KB

english, 2012

9

Characterization and functional consequences of delayed rectifier current transient in ventricular repolarization

Gintant, Gary A.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

2000

Language:

english

File:

PDF, 458 KB

english, 2000

10

Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations

Gintant, Gary, Kaushik, Emily Pfeiffer, Feaster, Tromondae, Stoelzle-Feix, Sonja, Kanda, Yasunari, Osada, Tomoharu, Smith, Godfrey, Czysz, Katherine, Kettenhofen, Ralf, Lu, Hua Rong, Cai, Beibei, Shi,

Journal:

Regulatory Toxicology and Pharmacology

Year:

2020

File:

PDF, 2.29 MB

2020

11

On a Newly Proposed In Vitro Proarrhythmia Model

Journal:

Journal of Cardiovascular Pharmacology

Year:

2003

Language:

english

File:

PDF, 143 KB

english, 2003

12

The Cardiac Safety Research Consortium enters its second decade: An invitation to participate

Turner, J. Rick, Kowey, Peter R., Rodriguez, Ignacio, Cabell, Christopher H., Gintant, Gary, Green, Cynthia L., Kunz, Barbara Lopez, Mortara, Justin, Sager, Philip T., Stockbridge, Norman, Wright, The

Journal:

American Heart Journal

Year:

2016

Language:

english

File:

PDF, 221 KB

english, 2016

13

Functional consequences of methionine oxidation of hERG potassium channels

Zhi Su, James Limberis, Ruth L. Martin, Rong Xu, Katrin Kolbe, Stefan H. Heinemann, Toshinori Hoshi, Bryan F. Cox, Gary A. Gintant

Journal:

Biochemical Pharmacology

Year:

2007

Language:

english

File:

PDF, 780 KB

english, 2007

14

Ventricular rate adaptation: A novel, rapid, cellular-based in-vitro assay to identify proarrhythmic and torsadogenic compounds

Jonathon R. Green, Gilbert J. Diaz, James T. Limberis, Kathryn A. Houseman, Zhi Su, Ruth L. Martin, Bryan F. Cox, Stan Kantor, Gary A. Gintant

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 634 KB

english, 2011

15

Site of action of local anesthetics on heart fibers

Lawrence H. Frame, Gary A. Gintant, Brian F. Hoffman

Journal:

The American Journal of Cardiology

Year:

1981

Language:

english

File:

PDF, 153 KB

english, 1981

16

Block of hERG channel by ziprasidone: Biophysical properties and molecular determinants

Zhi Su, Jun Chen, Ruth L. Martin, Jeffrey S. McDermott, Bryan F. Cox, Murali Gopalakrishnan, Gary A. Gintant

Journal:

Biochemical Pharmacology

Year:

2006

Language:

english

File:

PDF, 473 KB

english, 2006

17

Can Nonclinical Repolarization Assays Predict the Results of Clinical Thorough QT Studies? Results from a Research Consortium

Park, Eunjung, Gintant, Gary A, Bi, Daoqin, Kozeli, Devi, Pettit, Syril D, Pierson, Jennifer B, Skinner, Matthew, Willard, James, Wisialowski, Todd, Koerner, John, Valentin, Jean-Pierre

Journal:

British Journal of Pharmacology

Year:

2017

Language:

english

File:

PDF, 1.37 MB

english, 2017

18

Drug-induced Proarrhythmia and Torsade de Pointes: A Primer for Students and Practitioners of Medicine and Pharmacy

Turner, J. Rick, Rodriguez, Ignacio, Mantovani, Emily, Gintant, Gary, Kowey, Peter R., Klotzbaugh, Ralph J., Prasad, Krishna, Sager, Philip T., Stockbridge, Norman, Strnadova, Colette

Journal:

Journal of Clinical Pharmacology

Year:

2018

Language:

english

File:

PDF, 382 KB

english, 2018

19

The Roles of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes in Drug Discovery: Managing In Vitro Safety Study Expectations

Gintant, Gary, Traebert, Martin

Journal:

Expert Opinion on Drug Discovery

Year:

2020

File:

PDF, 1.02 MB

2020

20

Preclinical Torsades-de-Pointes Screens: Advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk

Gary A. Gintant

Journal:

Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 648 KB

english, 2008

21

A novel Na+-dependent slow current component in canine cardiac Purkinje fibers

Gary A. Gintant

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1989

Language:

english

File:

PDF, 98 KB

english, 1989

22

Ion Channel Toolbox for Cardiac Safety Evaluation

Martin, Ruth L., Limberis, James T., Liu, Xiaoqin, Houseman, Kathryn A., Su, Zhi, Gintant, Gary A., Cox, Bryan F.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 57 KB

english, 2009

23

ETA Receptor Blockade With Atrasentan Prevents Hypertension With the Multitargeted Tyrosine Kinase Inhibitor ABT-869 in Telemetry-instrumented Rats

Banfor, Patricia N, Franklin, Pamela A, Segreti, Jason A, Widomski, Deborah L, Davidsen, Steven K, Albert, Daniel H, Cox, Bryan F, Fryer, Ryan M, Gintant, Gary A

Journal:

Journal of Cardiovascular Pharmacology

Year:

2009

Language:

english

File:

PDF, 198 KB

english, 2009

24

In Vitro Preclinical Cardiac Assessment of Tolterodine and Terodiline: Multiple Factors Predict the Clinical Experience

Martin, Ruth L, Su, Zhi, Limberis, James T, Palmatier, Jason D, Cowart, Marlon D, Cox, Bryan F, Gintant, Gary A

Journal:

Journal of Cardiovascular Pharmacology

Year:

2006

Language:

english

File:

PDF, 540 KB

english, 2006

25

Predictive, non-GLP models of secondary pharmacodynamics: putting the best compounds forward

Glenn A Reinhart, Ryan M Fryer, Mark A Osinski, James S Polakowski, Bryan F Cox, Gary A Gintant

Journal:

Current Opinion in Chemical Biology

Year:

2005

Language:

english

File:

PDF, 136 KB

english, 2005

26

The ‘overly-sensitive’ heart: sodium channel block and QRS interval prolongation

Gary A Gintant, David J Gallacher, Michael K Pugsley

Journal:

British Journal of Pharmacology

Year:

2011

Language:

english

File:

PDF, 295 KB

english, 2011

27

Quinidine-Induced Early Afterdepolarizations and Triggered Activity

CHARLES ANTZELEVITCH, JORGE M. DAVIDENKO, SERGE SICOURI, LAWRENCE COHEN, ARTHUR IODICE, ROBERT GOODROW, GARY A. GINTANT

Journal:

Journal of Cardiovascular Electrophysiology

Year:

1989

Language:

english

File:

PDF, 5.39 MB

english, 1989

28

AN IN VITRO EXAMINATION OF DELAYED REPOLARIZATION: HOW PLASMA PROTEIN BINDING INFLUENCES DRUG EFFECTS

James T. Limberis, Jeffrey S. McDermott, Heinz J. Salmen, Zhi Su, Ann Mikhail, Jonathon R. Green, Gary A. Gintant, Ruth L. Martin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2007

Language:

english

File:

PDF, 59 KB

english, 2007

29

Different local anesthetic characteristics of charged and uncharged forms of lidocaine and other antiarrhythmic drugs in canine cardiac purkinje fibers

Gary A. Gintant, Brian F. Hoffman

Journal:

The American Journal of Cardiology

Year:

1982

Language:

english

File:

PDF, 153 KB

english, 1982

30

Comprehensive In Vitro Proarrhythmia Assay (CiPA) Update from a Cardiac Safety Research Consortium / Health and Environmental Sciences Institute / FDA Meeting

Strauss, David G., Gintant, Gary, Li, Zhihua, Wu, Wendy, Blinova, Ksenia, Vicente, Jose, Turner, J. Rick, Sager, Philip T.

Journal:

Therapeutic Innovation & Regulatory Science

Year:

2018

Language:

english

File:

PDF, 348 KB

english, 2018

31

Temperature Effects on Pharmacologic Enhancement of L-Type Calcium Current

Su, Zhi, Liu, Xiaoqin, Martin, Ruth L., Cox, Bryan F., Gintant, Gary A.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 79 KB

english, 2012

32

Do hERG Enhancers and Blockers Compete?

Liu, Xiaoqin, Limberis, James T., Su, Zhi, Houseman, Kathryn A., Diaz, Gilbert J., Gintant, Gary A., Cox, Bryan F., Martin, Ruth L.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 43 KB

english, 2009

33

In Vitro Cardiac Safety Profiling of a Novel Benzyl-Ethylamine Compound

Liu, Xiaoqin, Limberis, James T., Thomas, Sheila, Su, Zhi, Gintant, Gary A., Cox, Bryan F., Giranda, Vincent L., Martin, Ruth L.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 39 KB

english, 2010

34

Utility of hERG Assays as Surrogate Markers of Delayed Cardiac Repolarization and QT Safety

Gintant, Gary, Su, Zhi, Martin, Ruth, Cox, Bryan

Journal:

Toxicologic Pathology

Year:

2006

Language:

english

File:

PDF, 479 KB

english, 2006

35

A novel intravenous vehicle for preclinical cardiovascular screening of small molecule drug candidates in rat

Banfor, Patricia N., Gintant, Gary A., Lipari, John M., Zocharski, Philip D.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2016

Language:

english

File:

PDF, 766 KB

english, 2016

36

Assessing cardiac safety in oncology drug development

Seltzer, Jonathan H, Gintant, Gary, Amiri-Kordestani, Laleh, Singer, Jack, Koplowitz, Luana Pesco, Moslehi, Javid J, Barac, Ana, Yu, Anthony F.

Journal:

American Heart Journal

Year:

2019

Language:

english

File:

PDF, 532 KB

english, 2019

37

Cardiovascular Effects of Torcetrapib in Conscious and Pentobarbital-anesthetized Dogs

Polakowski, James S, King, Andrew J, Campbell, Thomas J, Nelson, Richard A, Preusser, Lee C, Kempf-Grote, Anita J, Marsh, Kennan C, Gintant, Gary A, Cox, Bryan F, Mittelstadt, Scott W

Journal:

Journal of Cardiovascular Pharmacology

Year:

2009

Language:

english

File:

PDF, 221 KB

english, 2009

38

Integrated and translational nonclinical in vivo cardiovascular risk assessment: Gaps and opportunities

Berridge, Brian R., Hoffmann, Peter, Turk, James R., Sellke, Frank, Gintant, Gary, Hirkaler, Gerald, Dreher, Kevin, Schultze, A. Eric, Walker, Dana, Edmunds, Nick, Halpern, Wendy, Falls, James, Sander

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 198 KB

english, 2013

39

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

Sager, Philip T., Gintant, Gary, Turner, J. Rick, Pettit, Syril, Stockbridge, Norman

Journal:

American Heart Journal

Year:

2014

Language:

english

File:

PDF, 555 KB

english, 2014

40

CiPA challenges and opportunities from a non-clinical, clinical and regulatory perspectives. An overview of the safety pharmacology scientific discussion

Wallis, Rob, Benson, Charles, Darpo, Borje, Gintant, Gary, Kanda, Yasunari, Prasad, Krishna, Strauss, David G., Valentin, Jean-Pierre

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2018

Language:

english

File:

PDF, 1.12 MB

english, 2018

41

The evaluation and management of drug effects on cardiac conduction (PR and QRS Intervals) in clinical development

Nada, Adel, Gintant, Gary A., Kleiman, Robert, Gutstein, David E., Gottfridsson, Christer, Michelson, Eric L., Strnadova, Colette, Killeen, Matthew, Geiger, Mary Jane, Fiszman, Mónica L., Koplowitz, L

Journal:

American Heart Journal

Year:

2013

Language:

english

File:

PDF, 358 KB

english, 2013

42

Predictivity of non-clinical repolarization assay data for clinical TQT data in FDA database

Valentin, Jean-Pierre, Koerner, John, Willard, James, Park, Eun Jung, Bi, Daoqin, Link, William, Fiszman, Monica, Kozeli, Devi, Skinner, Matt, Cantilena, Louis, Gintant, Gary, Wisialowski, Todd, Petti

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 88 KB

english, 2013

43

Introduction to biological complexity as a missing link in drug discovery

Gintant, Gary A., George, Christopher H.

Journal:

Expert Opinion on Drug Discovery

Year:

2018

Language:

english

File:

PDF, 1.71 MB

english, 2018

44

An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation

Journal:

Pharmacology & Therapeutics

Year:

2011

Language:

english

File:

PDF, 515 KB

english, 2011

45

Electrophysiologic Characterization of a Complex hERG Channel Activator

Su, Zhi, Limberis, James, Souers, Andrew, Kym, Philip, Mikhail, Ann, Houseman, Kathryn, Diaz, Gilbert, Martin, Ruth L., Cox, Bryan F., Gintant, Gary A.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 42 KB

english, 2009

46

The Canine Purkinje Fiber: An In Vitro Model System for Acquired Long QT Syndrome and Drug-Induced Arrhythmogenesis

Gintant, Gary A., Limberis, James T., McDermott, Jeff S., Wegner, Craig D., Cox, Bryan F.

Journal:

Journal of Cardiovascular Pharmacology

Year:

2001

Language:

english

File:

PDF, 1.35 MB

english, 2001

47

High extracellular glucose impairs cardiac E-C coupling in a glycosylation-dependent manner

Ren, Jun, Gintant, Gary A., Miller, Richard E., Davidoff, Amy J.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

1997

Language:

english

File:

PDF, 141 KB

english, 1997

48

The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and d, l-sotalol

James T. Limberis, Jeff S. McDermott, Heinz J. Salmen, Zhi Su, Ann Mikhail, Jonathon R. Green, Bryan F. Cox, Gary A. Gintant, Ruth L. Martin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2007

Language:

english

File:

PDF, 634 KB

english, 2007

49

Human ex-vivo action potential model for pro-arrhythmia risk assessment

Page, Guy, Ratchada, Phachareeya, Miron, Yannick, Ghetti, Andrea, Miller, Paul, Reynolds, Jack, Steiner, Guido, Greiter-Wilke, Andrea, Polonchuk, Liudmila, Traebert, Martin, Gintant, Gary A., Abi-Gerg

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2016

Language:

english

File:

PDF, 48 KB

english, 2016

50

WITHDRAWN: Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics

Vargas, Hugo M., Bass, Alan S., Breidenbach, Alexander, Feldman, Hal S., Gintant, Gary A., Harmer, Alexander, Heath, Bronagh, Hoffmann, Peter, Lagrutta, Armando, Leishmann, Derek, McMahon, Nick, Mitte

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2008

Language:

english

File:

PDF, 16 KB

english, 2008

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